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Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident cardiovascular disease, in particular heart failure. Here we show that homozygous deletion (homozygous tm1a, tm1b or tm1d alleles) of Myo18a in mouse is embryonic lethal. Due to our privacy policy, only current members can send messages to people on ResearchGate. Universität Göttingen. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and Aims -Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Die 25-jährige Studentin engagiert sich in der Gruppierung Basisdemokratische Linke in Göttingen, wo der Schock tief sitzt. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. 207 likes. The giant sarcomere protein titin is important in both heart health and disease. We combined a geno... Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Methods 1 für Adressen und Telefonnummern Recent reports suggest that mammalian embryonic coronary endothelium (CoE) develops from the sinus venosus and ventricular endocardium. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Cuvillier Göttingen (in Zusammenarbeit mit. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . Im Wintersemester 1921/22 wurde Pauli planmässiger Assistent von Professor Max Born (Link verlässt diese Seite).Born kehrte in diesem Jahr an seine Alma Mater zurück, an der er sich bereits 1909 habilitiert hatte. A personal tribute to Johann Caspar Rüegg (1930–2018): milestones of muscle research, JACBTS Gotzmann Linke Published SupplFigure, Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis, Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1, Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo, P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities, Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening, Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load, Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, Genetically Engineered Human Stem-Cell Derived Cardiomyocytes to Investigate the Function of Cronos Titin, Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ, Supplementary Figures&Table Nat-Commun Revision Final corrected, Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish, Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Placenta-Derived Adherent Stromal Cells Improve Diabetes Mellitus-Associated Left Ventricular Diastolic Performance: Placenta Stromal Cells and Diastolic Relaxation, Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function, Supplementary Figure S1 for Unger et al., Acta Neuropathol Commun. We used hetero‐ and homozygous R349P desmin... Background 205 likes. E-Mail: neurologie.sekretariat(at)med.uni … Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. 96 Einträge zu Wolfgang Link mit aktuellen Kontaktdaten, Öffnungszeiten und Bewertungen ☎ Das Telefonbuch - Ihre Nr. Current projects: Public relations activity at Reinshof He has written four works of comparative literature and psychology of art, now considered standards of their genre. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. Professor of Physiology and Department Chair, Adjunct Professor of Cardiac Mechanotransduction, Professor and Chair of Cardiovascular Physiology, Titin Gene and Protein Functions in Passive and Active Muscle, Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes, Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin, Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx), Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle, Nicotinamide for the treatment of heart failure with preserved ejection fraction, Graded Titin Cleavage Uncovers the Protein's Role for Sarcomere Structure and Force Generation of Contracting Muscle, Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism, Functional characterization of novel alpha-helical rod domain desmin (DES) pathogenic variants associated with dilated cardiomyopathy, atrioventricular block and a risk for sudden cardiac death, The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease, Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation, Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs. Highlights Left ventricular (LV) diastolic dysfunction is among others attributed to cardiomyocyte stiffness. Methods Here, we ha... Loss of cardiac macroautophagy/autophagy impairs heart function, and evidence accumulates that an increased autophagic flux may protect against cardiovascular disease. Die Telefonnummer 0551 9 48 00 finden Sie ganz oben auf der Seite. 1984: Dr. rer. Here, we characterise the molecular stru... Background Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. This file is licensed under the Creative Commons Attribution 3.0 Unported license. Daniel Siebrecht-Schöll, 2019: Breeding analysis of eight winter faba bean genotypes for mixed cropping with winter wheat. Bar graphs represent the mean ± SEM of splenic (A) CCR2, (B) MCP-1, (C) CX3CR1, and (D) CX3CL1 gene expression, as indicated, after normalization to the housekeeping gene 18S using the 2−ΔCt formula and normalized to the WT group, wh... Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2). Universität Göttingen. Auf LinkedIn können Sie sich das vollständige Profil ansehen und mehr über die Kontakte von Wolfgang Link und Jobs bei ähnlichen Unternehmen erfahren. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. So far, only a limited number of DES pathogenic variants have been identified... A detailed description of pathophysiological effects that viruses exert on their host is still challenging. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopathies and cardiomyopathies with marked clinical variability. Kontakte Fraktion Göttinger Linke . Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). SP... Alle tierischen Lebewesen, selbst Einzeller, bewegen sich fort. This file contains the Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. Wolfgang A. Linke Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin prot... Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Webseiten der Georg-August-Universität Göttingen. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify how titin-based forces define myocyte ultrastructure and mechanics. The giant protein titin forms a continuous filament network in the sarcomeres of striated muscle cells, where it determines passive tension development and modul... Membrane deformation by proteins is a universal phenomenon that has been studied extensively in eukaryotes but much less in prokaryotes. Methods: E-Mail: dialog@vobakg.de . Various professional articles, publications and lectures on general corporate law related issues as well as capital markets subjects. : 0561 7893-0. Der Seulinger ist seit fast acht Jahren hauptamtlicher Bürgermeister, politisch engagiert er sich aber schon wesentlich länger: Vor 30 Jahren trat er in die SPD ein und wurde schnell in den Seulinger Gemeinderat gewählt. Aims: The heart is constantly challenged with acute bouts of stretching or overload. Erstes Album [wolf:gang] 25.08.18 Fraktion Göttinger Linke Neues Rathaus, Zi. Posttranslational modifications of titin from cardiac muscle: how, where and what for? Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Briefpostadresse 37099 Göttingen . To o... Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought. International space missions with ESA and NASA. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Mesenchymal stromal cells (MSC) have cardiac-protective properties. Publications. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. Desmin is the major intermediate filament (IF) protein in human heart and skeletal muscle. Seif Eldin Gasim, 2003: Winter-hardy faba bean: Applied genetic research on the reproductive mode of the European gene pool. Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. Aims: We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. agric. The giant protein titin is thought to be required for sarcomeric integrity in mature myocytes, but direct evidence for this hypothesis is limited. Richtige Adressen und Telefonnummern finden! 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. Languages. Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Gregor Welna, 2014: Genetische Analysen für eine markergestützte Verbesserung der Trockenstresstoleranz von Winterackerbohnen. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contr... Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. Here, we describe a mouse model in which Z-disc-anchored TTN is depleted in adult skeletal muscles. Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. Vicia faba L. is a partially allogamous plant, with an intermediate level of cross- and of self-fertilization, realized by honey and bumble bees. two unstructured segments. Rationale: Although several studies in non-mammalian vertebrates have proven that extracardiac endothelial cells also participate in CoE development, the contribution of such cells to mammalian CoE is regarded to be minor and... Elucidating the biological mechanisms behind increased myocardial compliance following acute myocardial stretching and their role in cardiac diastolic (dys)function. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Wolfgang. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. English, German. Dahl salt-sensitive (DSS) rats and control rats were fed... Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Wolfgang Rode Innenarchitekt in Göttingen im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Wolfgang Rode Innenarchitekt Göttingen PmtA catalyzes the successive three-step N -... Background: Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. Elevating NAD ⁺ by oral supple... Striated muscle responds to mechanical overload by rapidly up-regulating the expression of the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to titin N2A in the I-band region. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. TTNtv are also encountered in [sim]1% of the general population, where they may be silent, perhaps reflecting allelic factors. Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. Stadt Göttingen Breslauer Straße 2 37085 Göttingen. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against... Background: All rights reserved. The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Berufserfahrung, Kontaktdaten, Portfolio und weitere Infos: Erfahr mehr – oder kontaktier Wolfgang H. Geiger direkt bei XING. Die Aktin- und Myosinfilamente treten durch Bildung bzw. 930/931 (9.Stock) Hiroshimaplatz 1-4 37083 Göttingen Telefon 05 51-4 00 23 47 Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD ⁺ ). Imbalances in protein homeostasis caused by mutant desmin, 234th ENMC International Workshop: Chaperone dysfunction in muscle disease, December 8-10th 2017, Naarden, Netherlands, A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. Join ResearchGate to contact this researcher and connect with your scientific community. Using intravit... Background: Accordingly, regulated protein decay is critical to maintain cardiac function. : You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. Voges, 2007: Genetische Analyse von Heterosis im jüngsten Stadium einer Pflanze, als Embryo, am Beispiel der Fababohne (, Franziska Roth, 2010: Evaluierung von Winterackerbohnen als Zwischenfrucht für eine ökologische Biogasproduktion. We analyzed 2 independent German families with clinical, geneti... Background: Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Reminiscent of Myo18b, Myo18a was highly exp... Cardiac functionality is dependent on a balanced protein turnover. Tel. Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Only verified researchers can join ResearchGate and send messages to other members. Here, we report a large, multi-generational family (78 members) with ASD combined with a late-onset dilated cardiomyopathy and further characterize the consequences of mutant α-actin. Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. Zenker Ofenbackform Auflaufform mit Buch Low-Carb-Aufläufe von Wolfgang Link Mit dem 2-teiligen Set mit Ofenbackform und Low-Carb-Aufläufe Buch von Zenker können sie nicht nur tolle Rezepte nachkochen, sondern können auch noch Ihrer Traumfigur ein Stückchen näherkommen. Wolfgang Engel (* 18. The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Es gibt 30+ Personen namens „Wolfgang Link“, die LinkedIn zum Austausch von Informationen, Ideen und Karrierechancen nutzen. Fax: 0561 7893-1311. Small heat shock proteins such as alphaB-crystallin (aBC) translocate under physiological or pathological stress to the titin springs. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the de... Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). With this reproductive behaviour, breeding methods appropriate for faba bean should be general solutions of which the methods for self-fertilizing and cross-fertilizing crops should be just extreme, marginal cases. Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. However, testing these mechanical hypotheses on native molecules in their natural environment remains inaccessible to conventional genetics, biophysics and molecular biology tools. Supplementary Figure Set for Unger et al., Acta Neuropathol Commun. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Universitätsmedizin Göttingen Klinik für Neurologie Robert-Koch-Straße 40 37075 Göttingen . 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. We show that under mechanical... Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Research Institution in Göttingen, Germany. Anbieter: Volksbank Kassel Göttingen eG. application of PLacenta-eXpanded (PLX) MSC-like cells (PLX) improves LV diastolic relaxation in streptozotocin (STZ)-induced diabetic mice and i... Myopathies encompass a wide variety of acquired and hereditary disorders. Crucial role of protein kinase G in regulating Ca2(+)/calmodulin-dependent protein kinase-II activity and oxidative stress: The diastolic function modulation via PKG-dependent CaMKII phosphorylation and oxidation. The correct name should be W. A. Linke, which is shown correctly in the authorgroup section above. The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. Research Assistant, Mathematical Institute, University of Göttingen. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. November 1940 in Ludwigshafen; † 7. Im Profil von Wolfgang Link sind 5 Jobs angegeben. nat., University of Göttingen. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. Wolfgang Victor Ruttkowski is a scholar of literature and culture. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Indeed, there is a tight link in terms of shared risk factors and mechanisms... AimsOur aim was to investigate the effect of nitric oxide (NO)-independent activation of soluble guanylyl cyclase (sGC) on cardiomyocyte function in a hypertensive animal model with diastolic dysfunction and in biopsies from human heart failure with preserved ejection fraction (HFpEF).Methods

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